Acute heart failure due to dilated cardiomyopathy exacerbated by systemic parechovirus A1 infection in an infant

Parechovirus A1 (PeV-A1) often causes mild respiratory or gastrointestinal disease. Herein we report a case of acute heart failure due to dilated cardiomyopathy exacerbated by PeV-A1 infection in 10-month-old infant. He was brought our hospital with distress and compensated shock. Echocardiogram showed left ventricle severe mitral regurgitation, consistent cardiomyopathy. confirmed (1) positive PCR test results for PeV-A multiple anatomical sites, including blood, stool, throat, (2) the genetic sequence viral protein, (3) an increase paired serum PeV-A1-specific neutralizing antibody titers. A few, scattered reports infants young children also indicate association between myocarditis and/or infection. In conclusion, could be associated exacerbation myocardial diseases children; thus needs evaluated as cause such condition.